Molecular Characterization of the Equine Herpesvirus 1 Strains RacL11 and Kentucky D
نویسندگان
چکیده
منابع مشابه
Comparative Genomic Sequencing and Pathogenic Properties of Equine Herpesvirus 1 KyA and RacL11
Equine herpesvirus 1 (EHV-1) is a major pathogen affecting equines worldwide. The virus causes respiratory disease, abortion, and, in some cases, neurological disease. EHV-1 Kentucky A (KyA) is attenuated in the mouse and equine, whereas wild-type pathogenic strain RacL11 induces severe inflammatory infiltration of the lung, causing infected mice to succumb. The complete DNA sequencing of the K...
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In this study, we attempted to express twelve glycoproteins of equine herpesvirus-1 (EHV-1) in 293T cells and to characterize these using monoclonal antibodies (MAbs) and horse sera against EHV-1. Expression of glycoprotein B (gB), gC, gD, gG, gI and gp2 was recognized by immunoblot analysis using horse sera, but that of gE, gH, gK, gL, gM and gN was not. Four MAbs recognized gB, four recognize...
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Equine herpesvirus 1 (EHV-1) is a major cause of epidemic abortion, neonatal mortality, respiratory disease and neurological disorders in horses. In South America, the virus has been isolated in Brazil, Argentina and Colombia. In Chile pathological findings from one aborted foetus have been reported, and in Uruguay only serological data about EHV-1 activity have been found. Some pathological fi...
متن کاملIdentification and characterization of equine herpesvirus
19 Major histocompatibility complex class I (MHC-I) molecules play an important role in host 20 immunity to infection by presenting antigenic peptides to cytotoxic T lymphocytes (CTL), which 21 recognize and destroy virus-infected cells. Members of Herpesviridae have developed multiple 22 mechanisms to avoid CTL recognition by virtue of downregulation of MHC-I on the cell surface. 23 We report ...
متن کاملEquine herpesvirus-1 consensus statement.
Equine herpesvirus-1 is a highly prevalent and frequently pathogenic infection of equids. The most serious clinical consequences of infection are abortion and equine herpesvirus myeloencephalopathy (EHM). In recent years, there has been an apparent increase in the incidence of EHM in North America, with serious consequences for horses and the horse industry. This consensus statement draws toget...
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ژورنال
عنوان ژورنال: Journal of Veterinary Medical Science
سال: 2007
ISSN: 0916-7250,1347-7439
DOI: 10.1292/jvms.69.573